Functionalization Chemistry for Polymers

Our group is interested in preparing functional polymeric materials through the incorporation of latent chemical functionalities for additional chemical reactions.  “Click” or robust, efficient and orthogonal (REO) chemistries are utilized in the laboratory to convert platform or modular systems into functional, active macromolecules.  Specifically, we are targeting a range of nanoparticle systems, such as degradable polyester systems prepared as pictorially illustrated below, for biomedical imaging, drug delivery, and therapy applications.

Selection of Peer-Reviewed Publications

Functionalized Poly(Caprolactone) — Oxime Chemistry

Iha, R. K.; Van Horn, B. A.; Wooley, K. L.  “Complex, Degradable Polyester Materials via Ketoxime Ether-Based Functionalization: Amphiphilic, Multifunctional Graft Copolymers and Their Resulting Solution-State Aggregates”, Journal of Polymer Science: Part A: Polymer Chemistry, 2010, 48, 3553-3563.

Van Horn, B. A.; Iha, R. K.; Wooley, K. L.  “Sequential and Single-Step, One-Pot Strategies for the Transformation of Hydrolytically Degradable Polyesters into Multifunctional Systems”, Macromolecules, 2008, 41, 1618-26.

Van Horn, B. A. and Wooley, K. L. “Crosslinked and Functionalized Polyester Materials Constructed using Ketoxime-Ether LinkagesSoft Matter, 2007, 3, 1032-1040.

Poly(styrene) Intramolecularly Crosslinked Nanoparticles — Synthesis and Properties

Harth, E.; Van Horn, B.; Lee, V. Y.; Germack, D. S.; Gonzoles, C. P.; Miller, R. D.; Hawker, C. J. “A facile approach to architecturally defined nanoparticles via intramolecular chain collapse”, Journal of the American Chemical Society, 2002, 124(29), 8653-8660.

Mackay, M. E.; Tuteja, A.; Duxbury, P. M.; Hawker, C. J. Van Horn, B.; Guan, Z.; Chen, G.; Krishnan, R. S. “General Strategies for Nanoparticle Dispersion”, Science, 2006, 311, 1740-1743.

Dukette, T. E.; Mackay, M. E.; Van Horn, B.; Wooley, K. L.; Drockenmuller, E.; Malkoch, M.; Hawker, C. J. “Conformation of Intramolecularly Cross-linked Polymer Nanoparticles on Solid Substrates”, Nano Letters, 2005, 5(9), 1704-1709.

Krishnan, R. S.; Mackay, M. E.; Hawker, C. J.; Van Horn, B. “Effect of ideal, organic nanoparticles on the flow properties of linear polymers: non-Einstein-like behavior”, Macromolecules, 2005, 38(19), 8000-8011.

Tuteja, A.; Mackay, M. E.; Hawker, C. J.; Van Horn, B. “Influence of Molecular Architecture on the Dewetting of Thin Polystyrene Films”, Langmuir, 2005, 21, 5770-5776.

Mackay, M. E.; Dao, T. T.; Tuteja, A.; Ho, D. L.; Van Horn, B.; Kim, H.-C.; Hawker, C. J. “Nanoscale effects leading to non-Einstein-like decrease in viscosity”, Nature Materials, 2003, 2(11), 762-766.

Research Interest and Publications